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Long-term follow-up of persons living with HIV
Life expectancy of persons living with HIV is reaching that of the general population. In consequence they are exposed to age-related comorbidities and complications, with both classical and HIV-...
Jean-Paul Viard.
December 2021, page 25
Cerebral cavernoma
Christine Kora,
Soumia El Arabi,
Widad Abbou,
Imane Skiker.
December 2021, page 50
Hughes-Stovin syndrome and Behçet disease
Sara Aouame,
Mehdi Badidi.
December 2021, page 51
Practice guide for the management of nightmare disorders
Nightmares are a common parasomnia that occurs mainly during REM sleep (paradoxical sleep) and at all ages. Recurrent nightmares, also known as nightmare disorder, are considered a clinical entity...
Agnès Brion.
December 2021, page 52
Clostridioides difficile: updated recommendations
Clostridioides difficile is a spore-forming anaerobic enteropathogen responsible for a wide spectrum of clinical features ranging from mild uncomplicated diarrhoea to severe debilitating disease,...
Frédéric Barbut,
Catherine Eckert,
Valérie Lalande,
Killian Le Neindre,
Jeanne Couturier.
December 2022, page 6
End of life: we must distinguish between euthanasia and assisted suicide
Pierre Le Coz.
December 2022, page 18
Diagnostic strategy for intrauterine lesions
The diagnostic strategy for intrauterine lesions is a question that arises very frequently in gynecological consultations. Endometrial cancer is more frequent in postmenopausal women and bleeding...
Jérémie Belghiti,
Sophie Egels,
Geoffroy Canlorbe.
December 2022, page 22
Microsatellite instability in endometrial cancer
The microsatellite instability reflects genetic instability that can be sought in tumors, using two methods, immunohistochemistry and molecular biology. Currently in France, a systematic evaluation...
Justine Varinot.
December 2022, page 30
Evolution of endometrial cancer surgery
Minimally invasive surgery (laparoscopic or robotic assisted) is currently recommended when surgery is envisaged, including for patients in the high risk group. The place of the uterine manipulator...
Geoffroy Canlorbe,
Marianne Nikpayam,
Jérémie Belghiti.
December 2022, page 35
Adjuvant treatments for endometrial cancer
Primary treatment for endometrial carcinoma is surgical. Adjuvant treatment is based on risk profile according to histological type, grade, lymphovascular involvement, FIGO stage and genomic...
Nicolas Meillan.
December 2022, page 41
Conservative treatments for endometrial cancer
Treatment for early endometrial cancer remains based on hysterectomy. However, in patients of reproductive age with a pregnancy desire, conservative alternative may be considered in case of...
Maha Eid,
Clémentine Gonthier,
Margot Bucau,
Martin Koskas.
December 2022, page 45
Ophthalmic shingles in an immunocompetent child
Hanan Ragragui Ouasmin,
Youssef Almheirat,
Hasnae Saddouk,
Siham Dikhaye,
Nada Zizi.
December 2022, page 51
Split hand sign in Charcot's disease
Christian Brosset,
Linh H Nguyen,
François Pruvot,
Anh Giang Thuc,
Hien Q Nguyen.
December 2022, page 52
Cranial involvement in Paget's disease
Ahmed Mougui,
Imane El Bouchti.
December 2022, page 53
Reversible cerebral vasoconstriction syndrome
Guillaume Delannoy,
Sébastien Gazzola.
December 2022, page 56
Vesiculo-pustular rash diffuse monomorphic
Hanane Daflaoui,
Hasna Saddouk,
Youssef Joudeh,
Siham Dikhaye,
Nada Zizi.
December 2022, page 59
Infant gastroesophageal reflux disease: physiological or pathological?
Gastroesophageal reflux (GER) is defined by the rise of gastric contents into the esophagus, with or without externalization. GER is very common in young infants, with a peak around 4 months, and...
Aurélie Bourchany,
Emmanuel Mas.
December 2022, page 74
To know the main occupational risks for maternity, related to the mother's work
Philippe Deruelle,
Florent Fuchs,
Noémie Ranisavljevic,
Martha Duraes.
December 2022, page 85
A history of women physicians (part one)
Jean-Noël Fabiani-Salmon.
December 2022, page 101
A history of women physicians (part two)
Jean-Noël Fabiani-Salmon.
December 2022, page 105
Therapeutic revolutions against melanoma
Responsible for 90% of skin cancer deaths, melanoma is the most aggressive skin tumor. Although the main risk factor is known, its incidence doubles every 10 years. Actually, intense and repeated...
Mathilde Amiot,
Céleste Lebbé.
March 2023, page 6
Epidemiology and risk factors of cancers of the upper aero-digestive tract
With more than 18.000 cases annually, head and neck cancers rank 5th among the most common cancers in France. In 90% of cases, it is squamous cell carcinoma. It reaches the oral cavity in 25%, 15%...
Nicolas Le Clerc.
March 2023, page 18
Imaging assessment and diagnostic guidance of upper aerodigestive tract cancers
The upper aerodigestive tract (UADT) has a complex anatomical architecture, which is only partially accessible by clinical examination and for which a detailed imaging analysis is necessary to...
Anne-Laure Gaultier,
Guillaume Reverdito,
Aurélien Saltel-Fulero.
March 2023, page 24
Therapeutic strategies for upper aerodigestive tract cancers
Upper aerodigestive tract squamous cell carcinomas are the most frequent head and neck cancers. They are generally associated with alcohol and tobacco, but can also be HPV-induced for the...
Julia Fanchette,
Caroline Halimi.
March 2023, page 31
Is surgery for ENT cancers less mutilating than in the past ?
Nicolas Le Clerc.
March 2023, page 38
Surveillance after cancer of the upper aerodigestive tract
Gérald Bonardel,
Nicolas Le Clerc.
March 2023, page 40
Cancers of the upper aerodigestive tract: the particular case of nasopharyngeal cancer
Nasopharyngeal carcinomas belong –in France- to the spectrum of rare diseases with several specificities owing to their etiology, epidemiology, diagnosis and therapeutics compared with other head...
François-Régis Ferrand,
Pierre Busson.
March 2023, page 45
Cancers of the upper aerodigestive tract: 10 key messages
Nicolas Le Clerc.
March 2023, page 52
Oral manifestations of secondary syphilis
Claire Lutz,
Anne-Laure Ejeil.
March 2023, page 55
Cystic retroperitoneal paraganglioma
Hajar Abdelouahab,
Salma Lokman,
Soumia El Arabi,
Ihssane Afilal,
Imane Kamaoui.
March 2023, page 58
First malaria vaccine recommended by WHO
RST,S/AS01, the first WHO recommended vaccine against malaria, is the result of decades of research. It is a recombinant protein vaccine which induces a protection against Plasmodium falciparum...
Wendé-Waoga Guillaume Zango,
Marie-Fleur Durieux,
Jean-François Faucher.
March 2023, page 71
Addiction to cannabis, cocaine, amphetamines, opiates, synthetic drugs
Laurent Karila,
Amine Benyamina.
March 2023, page 85
Opioid substitution therapy and harm reduction
Laurent Karila,
Amine Benyamina.
March 2023, page 94
Representations of death and relationship to death. Anthropological and psycho-existential approaches
Gilles Moutot,
Delphine Peyrat-Apicella,
Guillaume Grandazzi,
Guillaume Robert.
March 2023, page 96
Analyze and use the results of clinical studies in the perspective of good use. Critical analysis, clinical research and levels of evidence
Antoine Pariente,
Sibylle de Germay.
March 2023, page 103
The history of the Reichsuniversität Straßburg revealed
Christian Bonah,
Loïc Lutz.
March 2023, page 118
New antibiotics to deal with antibiotic resistance
The current increase in antibiotic resistance exposes to the risk of therapeutic impasse. To deal with this public health problem, developing new antibiotics that are effective (directly or in...
Pauline Huriez,
Benoît Pilmis.
September 2023, page 6
Evolutions of the "framework of benefits" system
In the field of compliance, the last thirty years have been marked by an evolution of the regulatory framework in order to adapt an anti-corruption system to the whole ecosystem of health...
Marianne Lahana,
Frédéric Glicenstein.
September 2023, page 15
The history of Hodgkin lymphoma
Hodgkin lymphoma was initially considered to be caused by infectious agents. The Hodgkin and Reed-Sternberg tumor cells are derived from mature B cells and transforming events were identified....
Christophe Fermé.
September 2023, page 21
Epidemiology of classical Hodgkin lymphoma
Classical Hodgkin lymphoma is a rare neoplasia but represents one of the most common cancers in adults younger than 40 years old. Epidemiology of Hodgkin lymphoma remains fascinating with specific...
Hervé Ghesquières.
September 2023, page 25
A better understanding of biological mechanisms
Hervé Ghesquières.
September 2023, page 29
Diagnosis and staging of Hodgkin lymphoma
Hodgkin lymphoma (HL) is composed of two distinct disease entities: classical HL (cHL) and nodular lymphocyte predominant HL (NLPHL). NLPHL is a rare entity with a specific therapeutic management....
Hervé Ghesquières.
September 2023, page 31
Frontline therapy for classical Hodgkin lymphoma patients
Upfront first-line chemotherapy is indicated for all features of classical Hodgkin's lymphoma, followed by involved node radiotherapy in early stages; the ABVD protocol (doxorubicin (Adriamycin),...
Cédric Rossi,
Olivier Casasnovas.
September 2023, page 39
Relapse of Hodgkin lymphoma: second and subsequent line treatments
Patients who fail first-line treatment can be cured with salvage chemotherapy followed by intensified therapy and hematopoietic stem cell autotransplantation. This treatment strategy is feasible...
Bénédicte Deau Fischer.
September 2023, page 48
Challenges of long-term follow up for Hodgkin lymphoma survivors
Challenge of Hodgkin lymphoma care is to obtain a high level of curability and minimize acute toxicities and long-term complications of chemotherapy and radiotherapy. A specific long-term...
Hervé Ghesquières.
September 2023, page 53
Toxicity of targeted therapies and immunotherapy with checkpointinhibitors in Hodgkin lymphoma
In patients at increased risk of recurrence or progression after autotransplantation, or in cases of relapse after autotransplantation or after at least two lines of treatment when intensive...
Jean-Marie Michot,
Julien Lazarovici.
September 2023, page 58
Fertility and gonadal disorders in patients with Hodgkin lymphoma
Christine Rousset-Jablonski.
September 2023, page 69
Cedell fracture
Xavier Fouilland,
Cécile Imfeld.
September 2023, page 77
Impact of the environment on health. Part 1. Child: the concept of the first 1 000 days
Umberto Simeoni,
Jean-Baptiste Armengaud.
September 2023, page 91
Leonardo da Vinci, visionary anatomist
Juliette Schenckéry.
September 2023, page 104
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