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Evolutions of the "framework of benefits" system
In the field of compliance, the last thirty years have been marked by an evolution of the regulatory framework in order to adapt an anti-corruption system to the whole ecosystem of health...
Marianne Lahana,
Frédéric Glicenstein.
September 2023, page 15
The history of Hodgkin lymphoma
Hodgkin lymphoma was initially considered to be caused by infectious agents. The Hodgkin and Reed-Sternberg tumor cells are derived from mature B cells and transforming events were identified....
Christophe Fermé.
September 2023, page 21
Epidemiology of classical Hodgkin lymphoma
Classical Hodgkin lymphoma is a rare neoplasia but represents one of the most common cancers in adults younger than 40 years old. Epidemiology of Hodgkin lymphoma remains fascinating with specific...
Hervé Ghesquières.
September 2023, page 25
A better understanding of biological mechanisms
Hervé Ghesquières.
September 2023, page 29
Diagnosis and staging of Hodgkin lymphoma
Hodgkin lymphoma (HL) is composed of two distinct disease entities: classical HL (cHL) and nodular lymphocyte predominant HL (NLPHL). NLPHL is a rare entity with a specific therapeutic management....
Hervé Ghesquières.
September 2023, page 31
Frontline therapy for classical Hodgkin lymphoma patients
Upfront first-line chemotherapy is indicated for all features of classical Hodgkin's lymphoma, followed by involved node radiotherapy in early stages; the ABVD protocol (doxorubicin (Adriamycin),...
Cédric Rossi,
Olivier Casasnovas.
September 2023, page 39
Relapse of Hodgkin lymphoma: second and subsequent line treatments
Patients who fail first-line treatment can be cured with salvage chemotherapy followed by intensified therapy and hematopoietic stem cell autotransplantation. This treatment strategy is feasible...
Bénédicte Deau Fischer.
September 2023, page 48
Challenges of long-term follow up for Hodgkin lymphoma survivors
Challenge of Hodgkin lymphoma care is to obtain a high level of curability and minimize acute toxicities and long-term complications of chemotherapy and radiotherapy. A specific long-term...
Hervé Ghesquières.
September 2023, page 53
Toxicity of targeted therapies and immunotherapy with checkpointinhibitors in Hodgkin lymphoma
In patients at increased risk of recurrence or progression after autotransplantation, or in cases of relapse after autotransplantation or after at least two lines of treatment when intensive...
Jean-Marie Michot,
Julien Lazarovici.
September 2023, page 58
Fertility and gonadal disorders in patients with Hodgkin lymphoma
Christine Rousset-Jablonski.
September 2023, page 69
Cedell fracture
Xavier Fouilland,
Cécile Imfeld.
September 2023, page 77
Impact of the environment on health. Part 1. Child: the concept of the first 1 000 days
Umberto Simeoni,
Jean-Baptiste Armengaud.
September 2023, page 91
Leonardo da Vinci, visionary anatomist
Juliette Schenckéry.
September 2023, page 104
Biotherapies in severe childhood asthma
Asthma is a chronic inflammatory disease of the lower airways and is one of the most common chronic conditions during childhood. The management of severe asthmatic patients must be...
Yanis Bouderbala,
Évangéline Clark,
Marion Tabardel,
Pascal Demoly,
Davide Caimmi.
December 2023, page 6
Salivary gland infections or sialadenitis
Salivary infections, or sialadenitis, affect all types of patients but are most common in elderly or dehydrated patients. Clinical signs include pain, skin erythema, gland oedema, fever and...
Joffrey Molher.
December 2023, page 21
Lithiasic salivary gland pathologies
Sialolithiasis is the most frequent pathology affecting the salivary glands. Almost 80% of these lithiasis affect the submandibular gland, in the Wharton duct whilst 20% occur in the parotid gland...
Domitille Camous.
December 2023, page 35
Hereditary systemic auto-inflammatory diseases associated with cryopyrin
CAPS (cryoprine-associated periodic syndromes) are a group of auto-inflammatory diseases of varying severity, most often beginning very early in life and characterized by febrile episodes, a...
Bénédicte Neven.
December 2023, page 58
Posterior sternoclavicular dislocation
Xavier Fouilland,
Florine Wojcieszak,
Cécile Imfeld,
Anne Le Coat.
December 2023, page 71
Dynamic scapula alata
Audrey Boutrois,
Martin Gry,
Georges Pfister.
December 2023, page 77
Spontaneous pneumomediastinum
Anne Le Coat,
Victor Hurpin,
Ophélie Pignon,
Xavier Fouilland.
December 2023, page 80
Sexual dysfunction after prostate cancer treatment
Changes in sexuality after prostate cancer treatment are very common, significantly impacting quality of life. Psychologically, body image, self-esteem and interpersonal relationships are...
Ala Chebbi.
December 2023, page 93
Why is the Hippocratic Oath so important?
Jean-Noël Fabiani-Salmon.
December 2023, page 104
Is ChatGPT reliable? Put to the test by medical students and teachers
Joël Ménard.
March 2024, page 12
Which vaccines for COPD patients?
Patients with chronic obstructive pulmonary disease (COPD) are at high risk of bacterial or viral respiratory infections, which can worsen their symptoms and trigger respiratory exacerbations....
Pierre-Régis Burgel.
March 2024, page 14
The choice of a life without children under the influence of societal concerns
Previously unpublished data from 2021 provide an update on the motivations of people who choose not to have children, considering a context of strong social pressure to conceive and a declining...
Charlotte Debest.
March 2024, page 17
Anatomy of memory
Memory phenomena involve neuron circuits and neurogenesis processes at the microscopic level. Nevertheless, the central role played by some key structures such as the hippocampus and the limbic...
Laurent Tatu.
March 2024, page 25
Neuropsychology of memory
In neuropsychology, memory is shown as a complex function composed of several memory systems. Five memory systems are proposed: working memory (or short term memory), episodic memory, semantic...
Francis Eustache.
March 2024, page 28
Memory tests
Memory tests used in clinical practice mainly concern anterograde memory through the evaluation of learning, short- or long-term retention, and retrieval of information. They use different types of...
Mickaël Laisney,
Peggy Quinette.
March 2024, page 32
Transient amnesias
Fausto Viader.
March 2024, page 41
How to deal with memory complaints
Memory complaint is a common condition in the general population and can indicate normal brain aging as well as incurable neurodegenerative disease or curable disorders. Therefore, the role of any...
Nicolas Villain.
March 2024, page 46
Memory disorders: 10 key messages
Fausto Viader.
March 2024, page 55
Stubborn metatarsalgias
Charlène Fraysse,
Victoria Picquendar,
Caroline Demurger,
Marion Gardies,
Sandrine Vlavonou.
March 2024, page 58
Waardenburg syndrome
Ayoub Boubekri,
Walid Atmani,
Mustapha Bensghir.
March 2024, page 59
Living with… prostate cancer
Roland Muntz.
March 2024, page 66
Urinary incontinence in children
Urinary incontinence in children and adolescents is most often of functional origin. Questioning and clinical examination with a bladder diary should look for underlying urological or neurological...
Hina Simonnet,
Pauline Lallemant-Dudek.
March 2024, page 76
Great evils, great plagues: epidemics
Lucile Douchin.
March 2024, page 96
Advances in antibiotic therapy for tuberculosis
Treatment of tuberculosis is experiencing significant advancements. For the first time, a therapeutic regimen based on rifapentine and moxifloxacin allows for a reduction of treatment duration of...
Thomas Maitre,
Lorenzo Guglielmetti,
Jérôme Robert,
Alexandra Aubry,
Nicolas Veziris.
June 2024, page 8
First consultations for insomnia and gait in general practice
Damien Léger,
Jonathan Taïeb.
June 2024, page 29
Pathophysiological hypothesis and diagnosis of insomnia disorder
All pathophysiological models place hyperarousal as a central process in the mechanisms of insomnia. These models differ, however, in terms of the importance and role of the variables explaining...
Jean-Arthur Micoulaud-Franchi,
Julien Coelho,
Léa Boileau,
Clélia Quiles,
Pierre-Alexis Geoffroy.
June 2024, page 38
Insomnia/sleep apnea: COMISA
Marie-Pia D'Ortho,
Amel Tebal,
Sarah Hartley.
June 2024, page 47
Sleep centers: from diagnosis to care
Sarah Hartley.
June 2024, page 60
Vesicant contact with cantharides
Maxence Jacquemet,
Clothilde Avisseau,
Côme Lourde.
June 2024, page 75
Hamstring hematoma
Charlène Fraysse,
Victoria Picquendar,
Livia Mannaioni,
Morgane Faivre d'Arcier,
Marius Siaud.
June 2024, page 76
COPD exacerbations
COPD exacerbations, characterized by an acute worsening of dyspnea and/or cough and sputum volume beyond daily variations, are a public health issue because of their frequency, the number of...
Simon Valentin,
Bruno Ribeiro Baptista,
Ari Chaouat,
François Chabot \.
June 2024, page 96
What are the indications for corticosteroid therapy in COPD?
In stable state chronic obstructive pulmonary disease (COPD), inhaled corticosteroids (ICS) should be used in case of frequent exacerbation only, associated with long-term bronchodilators including...
Gaëtan Deslée.
June 2024, page 100
Localized or generalized edema of the lower limbs
Stéphane Vignes,
Marie Essig.
June 2024, page 105
Developments in forensic medicine: the example of Haute-Normandie
Bernard Proust.
June 2024, page 115
When should short-term antibiotic therapy be chosen?
Reducing antibiotic exposure by shortening treatment duration is a public health priority that could mitigate the emergence of bacterial resistance, minimize adverse effects, and lower costs....
Emma D'Anglejan,
Frédérique Bouchand,
Aurélien Dinh.
October 2024, page 14
Infectious endocarditis: strategy for diagnosis
The diagnosis of infective endocarditis is often difficult because the clinical presentations are very heterogeneous. Epidemiology has evolved with more acute forms, different microorganisms, and...
Anne Bernard,
Nicolas Chane-Sone,
Fanny Dion,
Adrien Lemaignen.
October 2024, page 27
Complications of infective endocarditis
The high in-hospital mortality of patients with infective endocarditis (about 20%) is mainly due to its complications. These complications are essentially of cardiac, neurological, and infectious...
Faouzi Trojette,
Chloé Di Lena,
Yohann Bohbot,
Dan Rusinaru,
Christophe Tribouilloy.
October 2024, page 43
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